Alternative splicing and genomic stability
نویسندگان
چکیده
منابع مشابه
Alternative splicing and genomic stability.
Alternative splicing allows an organism to make different proteins in different cells at different times, all from the same gene. In a cell that uses alternative splicing, the total length of all the exons is much shorter than in a cell that encodes the same set of proteins without alternative splicing. This economical use of exons makes genes more stable during reproduction and development bec...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملAlternative Promoters Influence Alternative Splicing at the Genomic Level
BACKGROUND More and more experiments have shown that transcription and mRNA processing are not two independent events but are tightly coupled to each other. Both promoter and transcription rate were found to influence alternative splicing. More than half of human genes have alternative promoters, but it is still not clear why there are so many alternative promoters and what their biological rol...
متن کاملGenomic analysis of RNA alternative splicing in cancers.
Alternative splicing is an important and prevalent mechanism of gene regulation in higher eukaryotes. Nearly three quarters of human multi-exon genes are alternatively spliced. There is great interest in discovering alternative splicing events in the transcriptome of cancer cells, and in understanding how alternative splicing contributes to tumorigenesis. In this article, I will review recent a...
متن کاملEvolution and Alternative Splicing
In order to comprehend the influence of evolutionary changes in gene structure on the alternative splicing mechanism, we work on three related subjects: (i) conservation of exonintron sequences, (ii) splice site score changes and (iii) length data changes, across the vertebrate tree. We have analyzed conservation levels of human Alternative cassette exons (ACEs) ...
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ژورنال
عنوان ژورنال: Physical Biology
سال: 2004
ISSN: 1478-3967,1478-3975
DOI: 10.1088/1478-3967/1/2/c01